Ruben Waeytens

PhD Student

Prof. dr. ir. Ingmar Nopens - Ghent University
Prof. dr. Thomas De Beer - Ghent University

Research background

Traditionally, production of pharmaceuticals is realized using batch processing steps which can be fairly inefficient, time-consuming and poorly upscalable. Recent clarification by the regulatory authorities as well as the industry have accelerated the search for new manufacturing technologies. Consequently, a transition towards continuous manufacturing which includes real-time process monitoring and closed-loop control, has gained tremendous attention over the past few years. This because of the economic, environmental, safety and product-related advantages of a continuous manufacturing line. Driven by this change in mind-set, an innovative continuous from powder-to-tablet line (ConsiGmaTM-25, ColletteTM, GEA Pharma Systems) was developed for secondary manufacturing of pharmaceutical tablets.

Research objective

To fully profit from the advantages of continuous manufacturing a good process understanding and controllability are indispensable. The goal of my research is to improve the currently existing models for different unit operations within continuous direct compression. These models are then to be used in advanced control strategies.

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